Publications

A complete list is available on Google Scholar.

2026

Sini Nagpal and Greg Gibson. Pervasive Interactions between Exposures and Polygenic Risk can Inform more Effective Clinical and Behavioral Intervention. Nature Genetics
Sini Nagpal, Kosar Hooshmand, Piyushkumar Mundra, Mandy L. Ballinger, International Sarcoma Kindred Study (ISKS), Greg Gibson, David M. Thomas. A genome-wide association study of sarcoma suggests shared genetic overlap with rare variant susceptibility. (Under review)
CAR Warmerdam, Harm-Jan Westra, Adriaan van der Graaf, Marc Jan Bonder, Patrick Deelen, Tijs van Lieshout, Anke Jannie Landman, Mihkel Jesse, Benjamin J. Strober, Toni Boltz, Sandra Lapinska, Sini Nagpal, et al. Trans-eQTLs reveal the architecture of human gene regulatory networks. (Under review)

Kyle Gettler, Sini Nagpal, Savannah Washburn, Christopher Tastad, Jiayu Zhang, Ksenija Sabic, Mark Lazarev, Alain Bitton, Rita Cohen, Marc B. Schwartz, Arthur Barrie, Philip Gu, Philip Fleshner, Michelle Bao, Cristian Hernández-Rocha, Jacob McCauley, Maria Abreu, Subra Kugathasan, Dermot P. McGovern, Steven R. Brant, Richard H. Duerr, Mark S. Silverberg, John D. Rioux, Greg Gibson, Judy H. Cho. Post-operative ileum transcriptomics implicates sex-biased mechanisms of Crohn's disease recurrence. Gastroenterology.
Adriaan van der Graaf, Robert Warmerdam, Chiara Auwerx, Urmo Võsa, Maria Carolina Borges, Lude Franke, Zoltán Kutalik, eQTLGen Consortium. MR-link-2: pleiotropy robust cis Mendelian randomization validated in three independent reference datasets of causality. Nature Communications.
Krista Freimann, Anneke Brümmer, Robert Warmerdam, Tarran S. Rupall, Ana Laura Hernández-Ledesma, Joshua Chiou, Emily R. Holzinger, Joseph C. Maranville, Nikolina Nakic, Halit Ongen, Luca Stefanucci, Michael C. Turchin, eQTLGen Consortium, et al. Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus. Nature Communications.

Margaret Brown, Anne Dodd, Fang Shi, Emily Greenwood, Sini Nagpal, Vasantha L. Kolachala, Subra Kugathasan, Greg Gibson. Concordant B and T Cell Heterogeneity Inferred from the Multiomic Landscape of Peripheral Blood Mononuclear Cells in a Crohn's Disease Cohort. Journal of Crohn's and Colitis.

Courtney Astore, Shivam Sharma, Sini Nagpal, NIDDK IBD Genetics Consortium, David J. Cutler, John D. Rioux, Judy H. Cho, Dermot P.B. McGovern, Steven R. Brant, Subra Kugathasan, I. King Jordan, Greg Gibson. The role of admixture in rare variant contributions to inflammatory bowel disease. Genome Medicine.

Courtney Astore, Sini Nagpal, Greg Gibson. Mendelian Randomization Indicates a Causal Role for Omega-3 Fatty Acids in Inflammatory Bowel Disease. International Journal of Molecular Sciences.
Sini Nagpal, Raghav Tandon, Greg Gibson. Canalization of the Polygenic Risk for Common Diseases and Traits in the UK Biobank Cohort. Molecular Biology and Evolution.

Angela Mo*, Sini Nagpal*, Kyle Gettler, Talin Haritunians, Mamta Giri, Yael Haberman, Rebekah Karns, Jarod Prince, Dalia Arafat, Nai-Yun Hsu, Ling-Shiang Chuang, Carmen Argmann, Andrew Kasarskis, Mayte Suarez-Farinas, Nathan Gotman, Emebet Mengesha, Suresh Venkateswaran, Paul A. Rufo, Susan S. Baker, Cary G. Sauer, James Markowitz, Marian D. Pfefferkorn, Joel R. Rosh, Brendan M. Boyle, David R. Mack, Robert N. Baldassano, Sapana Shah, Neal S. LeLeiko, Melvin B. Heyman, Anne M. Griffiths, Ashish S. Patel, Joshua D. Noe, Sonia Davis Thomas, Bruce J. Aronow, Thomas D. Walters, Dermot P.B. McGovern, Jeffrey S. Hyams, Subra Kugathasan, Judy H. Cho, Lee A. Denson, Greg Gibson. Stratification of Risk of Progression to Colectomy in Ulcerative Colitis via Measured and Predicted Gene Expression. American Journal of Human Genetics. (*Equal contribution)
Hari K. Somineni, Sini Nagpal, Suresh Venkateswaran, David J. Cutler, David T. Okou, Talin Haritunians, Claire L. Simpson, Ferdouse Begum, Lisa W. Datta, Antonio J. Quiros, Jenifer Seminerio, Emebet Mengesha, et al. Whole-Genome Sequencing of African Americans Implicates Differential Genetic Architecture in Inflammatory Bowel Disease. American Journal of Human Genetics.
James P. Stevens, Vasantha L. Kolachala, Gaurav N. Joshi, Sini Nagpal, Greg Gibson, Nitika A. Gupta. Angiotensin-converting Enzyme-2 (ACE2) Expression in Pediatric Liver Disease. Applied Immunohistochemistry and Molecular Morphology.

Mark Pinese, Paul Lacaze, Emma M. Rath, Andrew Stone, Marie-Jo Brion, Adam Ameur, Sini Nagpal, Clare Puttick, Shane Husson, Dmitry Degrave, et al. The Medical Genome Reference Bank Contains Whole Genome and Phenotype Data of 2570 Healthy Elderly. Nature Communications.

Sini Nagpal*, Xiaoran Meng*, Michael P. Epstein, Lam C. Tsoi, Matthew Patrick, Greg Gibson, Philip L. De Jager, David A. Bennett, Aliza P. Wingo, Thomas S. Wingo, Jingjing Yang. TIGAR: An Improved Bayesian Tool for Transcriptomic Data Imputation Enhances Gene Mapping of Complex Traits. American Journal of Human Genetics. (*Equal contribution)

Sini Nagpal, Greg Gibson, Urko M. Marigorta. Pervasive Modulation of Obesity Risk by the Environment and Genomic Background. Genes.