Nagpal Lab
We develop statistical genetics and integrative genomics approaches to assess human disease risk, with the goal of advancing precision genomic medicine.
Koita Centre for Digital Health · Indian Institute of Technology Bombay
Research Focus
Polygenic Risk & Environment
Understanding how polygenic risk interacts with the environment to influence disease risk, and the clinical utility of PRSxE-based interventions.
Integrative Genomics
Integrating transcriptomics with genetics to improve risk stratification and patient outcomes, including disease progression, recurrence and treatment response.
Monogenic vs Polygenic Risk
Exploring how monogenic and polygenic risk interact - and to what extent polygenic background modulates the risk of rare pathogenic variants.
Ancestry & Health Equity
Developing ancestry-informed genetic risk assessment approaches to ensure precision medicine benefits extend equitably across diverse populations.
Latest News
- July 2026 Sini's paper on polygenic risk score-by-context (PGSxC) interactions and their utility published in Nature Genetics !
- June 2026 Nagpal Lab officially launches at the Koita Centre for Digital Health, IIT Bombay!
- May 2026 Sini presented a poster at the STATGEN2026: Conference on Statistics in Genomics and Genetics at Emory University, Atlanta, USA.